Selected Publications

Full list of publications can be found at:


Köster S, Upadhyay S, Philips JA. Why macrophages cannot LAP up TB. Autophagy. 2018 Jan 9:1-5. doi: 10.1080/15548627.2018.1425054. [Epub ahead of print] PMID:29313424

Köster S, Klevorn T, Papavinasasundaram K, Sassetti C, Portal-Celhay C, Philips, JA. Consequences of enhanced LC3-trafficking for a live, attenuated M. tuberculosis vaccine. Vaccine,


Köster S, Upadhyay S, Chandra P, Papavinasasundaram K, Yang G, Hassan A, Grigsby S, Mittal E, Park HS, Jones V, Hsu F, Jackson M, Sassetti C, Philips, JA. Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA, Proc. Natl. Acad. Sci., 2017: pii:20107792. doi: 10.1073/pnas.1707792114 (Epub ahead of print).


Portal-Celhay C, Tufariello JM, Srivastava S, Mehra A, Zahra A, Bean AJ, Ernst JD, Jacobs Jr. WR*, Philips JA.* Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent MHC class II antigen presentation, Nature Microbiol 2016: 2, 16232. (*equal contribution)

     Featured in Neyrolles, O. Bacterial Pathogenesis: A sand grain in antigen processing. Nature Microbiol 2016: 2, 16234. PMID: 27918496

     See Behind The Paper, Portal-Celhay C. The route towards T cell activation: how TB and I crossed paths:

Tinaztepe E, Wei J-R, Raynowska J, Portal-Celhay C, Thompson V, and Philips, JA. The role of metal dependent regulation of ESX-3 secretion on the intracellular survival of Mycobacterium tuberculosis, Infect Immun 2016; May 31, pii: IAI00197-16 [Epub ahead of print]; PMID:27245412.

Ouimet M, Koster S, Sakowski, E, Ramkhelawon B, Van Solingen C, Oldebeken S, Karunakaran D, Portal-Celhay C, Sheedy FJ, Ray TD, Cecchini K, Zamore PD, Rayner KJ, Marcel YL, Philips JA,* Moore KJ.* Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism, Nat Immunol 2016; 17 , 677-686. PMCID: PMC4873392. (*equal contribution)

Tufariello JM, Chapman JR, Kerantzas CA, Wong KW, Vilchèze C, Jones CM, Cole LE, Tinaztepe E, Thompson V, Fenyö D, Niederweis M, Ueberheide B, Philips JA*, Jacobs WR Jr*. Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E348-57; (*equal contribution)


Sakowski E, Koster S, Portal Celhay C, Park HS, Shrestha E, Hetzenecker SE, Maurer K, Cadwell K, Philips JA. Ubiquilin 1 Promotes IFN-gamma-induced xenophagy of Mycobacterium tuberculosis. PLOS Pathogens. 2015 Jul 30;11(7):e1005076.

Vaeth M, Zee I, Concepcion AR, Maus M, Shaw P, Portal-Celhay C, Zahra A, Kozhaya L, Weidinger C, Philips J, Unutmaz D, Feske S. Ca2+ Signaling but Not Store-Operated Ca2+ Entry is Required for the Function of Macrophages and Dendritic Cells. J Immunol., 2015 Aug 1;195(3):1202-17. Epub 2015 Jun 24.


Siegrist MS, Steigedal M, Ahmad R, Dragset MS, Mehra A, Philips JA, Carr SA, Rubin EJ. Mycobacterium Esx-3 Requires Multiple Components for Iron Acquisition. MBio. 2014 May 6;5(3): e01073-14. PMID 24803520. doi: 10.1128/mBio.01073-14.

Mehra A, Philips JA. Analysis of Mycobacterial Protein Secretion. Bio-protocol. 2014 4(12):


Mehra A*, Zahra A*, Thompson V, Sirisaengtaksin N, Wells A, Porto M, Koster, S, Penberthy K, Kubota Y, Dricot A, Rogan D, Vidal M, Hill DE, Bean AJ, Philips JA. Mycobacterium tuberculosis Type VII secreted effector EsxH targets host ESCRT to impair trafficking. PLOS Pathogens. 2013 Oct;9(10):e1003734. PMID 24204276; * equal contribution. doi: 10.1371/journal.ppat.1003734.

Cadwell, K Philips, JA. Autophagy meets phagocytosis. Immunity. 2013 Sept 19;39(3): 425-427. PMID: 24054324. doi: 10.1016/j.immuni.2013.08.027.

2012 and Prior, Select Publications

Philips, JA Ernst JD. Tuberculosis and Immunity. Annu. Rev. Pathol. 2012 7: 353-384. PMID: 22054143. doi: 10.1146/annurev-pathol-011811-132458.

Philips JA, Ernst JD. Directly observing therapy: a new view of drug tolerance in tuberculosis. Cell. 2011 Apr 1;145(1):13-4. PMID 21458661. doi: 10.1016/j.cell.2011.02.041.

Philips JA. Mycobacterial manipulation of vacuolar sorting. Cell Microbiol. 2008 Dec;10(12):2408-15. PMID 18783482. doi: 10.1111/j.1462-5822.2008.01239.x.

Philips JA, Porto MC, Wang H, Rubin EJ, Perrimon N. ESCRT factors restrict mycobacterial growth. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3070-5. PMID 18287038. doi: 10.1073/pnas.0707206105

Philips JA, Marty FM, Stone RM, Koplan BA, Katz JT, Baden LR. Torsades de pointes associated with voriconazole use. Transpl Infect Dis. 2007 Mar;9(1):33-6. PMID 17313469. doi: 10.1111/j.1399-3062.2006.00160.x.

Philips JA, Rubin EJ, Perrimon N. Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science. 2005 Aug 19;309(5738):1251-3. PMID 16020694. doi: 10.1126/science.1116006.

Agaisse H, Burrack LS, Philips JA, Rubin EJ, Perrimon N, Higgins DE. Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science. 2005 Aug 19;309(5738):1248-51. PMID 16020693. doi: 10.1126/science.1116008.